It depends if the road is a state road, a city road, or a County road.
State roads can be identified by black signs at the intersection (S-2-xxx). Call the SC DOT Highway Maintenance Department at 803.641.7665 to request repairs on a state road.
If you live in a city and the road is not a state road, call that city's Public Works Department.
If you live in the County and the road is not a State road, call the County Roads and Bridges Division at 803.642.1532.